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Novavax Confirms Efficacy Against Original and Variant COVID-19 Strains

Final analysis of NVX–CoV2373 in UK trial confirms 96% efficacy against original strain of COVID-19 and 86.3% against the B.1.1.7 variant.

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By: Kristin Brooks

Managing Editor, Contract Pharma

Novavax, Inc.’s Phase III trial of NVX–CoV2373 COVID-19 vaccine candidate demonstrated final efficacy of 96.4% against mild, moderate and severe disease caused by the original COVID-19 strain in the UK trial. The company completed analysis of its Phase 2b trial in South Africa, with efficacy of 55.4% among the HIV- negative trial participants in a region where the vast majority of strains are B1.351 escape variants. Across both trials, NVX-CoV2373 demonstrated 100% protection against severe dise...

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